Cat guardians

You are here because you are looking for help and have questions. All of us at VetImmune® are here because of our furchildren and because we want to help. Polyprenyl Immunostimulant™ is available to or through veterinarians, and your veterinarian needs to order it for you

Help with the order process:
download, print and bring the following documents to your veterinarian:

1 – Order form
  US form for US-based orders.​
  International order form for non-US orders

2 – Box insert
  Polyprenyl Immunostimulant™ information leaflet.
  Rhinotracheitis treatment brochure (optional).

3 – Research papers
 Legendre, AM & Bartges, JW. Effect of Polyprenyl Immunostimulant™ on the Survival Times of Three Cats with the Dry Form of Feline Infectious Peritonitis (FIP). 2009. J Fel Med Surg, 11, 624-626.
 Legendre, AM et al. Polyprenyl Immunostimulant™ treatment of cats with presumptive non-effusive feline infectious peritonitis in a field study, 2017. Front Vet Sci, 14 February 2017.
 Legendre, AM et al. Polyprenyl Immunostimulant™ in Feline Rhinotracheitis: Randomized Placebo-Controlled Experimental and Field Safety Studies. 2017 Front Vet Sci, 27 February 2017.

What is the dose I need for my pet?
The best way to determine the dose is to ask your veterinarian. If your cat has rhinotracheitis (herpes), you need to use the dose as indicated on the label: 0.5 mg/kg twice daily for 15 days. However, veterinarians may prescribe different doses or use PI in other diseases, for other indications. Your veterinarian will always remain the best source of information. Dr. Alfred Legendre of the University of Tennessee-Knoxville published several papers describing his clinical research with Polyprenyl Immunostimulant™.

How is Polyprenyl Immunostimulant™ administered?
Polyprenyl Immunostimulant™ has been formulated for oral administration. However, your veterinarian may order a different route.

Is Polyprenyl Immunostimulant™ safe? 
Yes. You may check more data by clicking here. Safety of Polyprenyl Immunostimulant™ has been tested in 390 cats in 10 states and used for disease control in over 1,000 cats, several dozen ferrets, dogs, birds, and mice. No adverse events were reported.

My cat hates taking PI. Is there anything I can do, such as adding PI to his favorite food? 
Most cats will object to taking any medication, or rather anything forced on them against their will. You need to work on your techniques of medication your cat with your veterinarian. PI is tasteless but its smell is recognized as offensive by some cats (albeit we know of two unrelated cats who actually craved PI). Masking the smell helps the process. Many cats agree taking PI in tuna juice. PI is unstable in tuna juice, so you need to get your cat lap it up immediately after mixing.

What if I start my cat on PI and later on it turns out that he/she does not have the disease? 
Polyprenyl Immunostimulant™ is safe, and it upregulates innate immunity regardless of the presence of the disease. Your cat will have no problems from the administration of PI. Healthy cats on our safety studies remained healthy.

Can Polyprenyl Immunostimulant™ be combined with other drugs?
You need to ask your veterinarian. Published research by Dr. Alfred Legendre provides information on the use of concurrent drugs.

I think my pet has an adverse response. What do I need to do?
You need to see your veterinarian immediately. If the veterinarian confirms that the adverse event is due to the medication and not to the progression of the disease, you need to file a report with the manufacturer Sass & Sass.

If you are a veterinarian:
You need to get to our order page and select an appropriate choice. Veterinarians need to register to access complete package of information. Veterinarians may place orders without registering too, by downloading our US order form for US veterinarians or our international order form for non-US veterinarians, completing it and sending to us by e-mail or fax (1-865-940-0042).

If you are not a veterinarian:
If you are a cat guardian, you need to download the package Insert and our US order form for US patients or our international order form for non-US patients and take those to your veterinarian. 
If you have any questions, please e-mail or call us at 1-209-600-7070.

May a veterinarian place an order and let the patient pay for it?
Yes. The order form provides that option. Veterinarians need to fill out the account information and order information sections and let patients complete the shipping information and payment information sections.

My veterinarian has not heard about PI. What information do I need to give him/her?
The best source of information for your veterinarian will be Veterinary Information Network (VIN) to which your veterinarian has an access through professional channels. You may download our package insert and research publications and take to your veterinarian along with the order form.

Do you require prescriptions? Can you fill a prescription?
No. We need to have an order form completed by veterinarians. We are not a pharmacy and cannot fill prescriptions. Veterinarians need to dispense Polyprenyl Immunostimulant™.

How do I order a refill?
Veterinarians need to indicate, in order information section of the order form, if they authorize refills using the same form or send in a separate form with every reorder.

What is the cost of the treatment?
You need to work this out with your veterinarian because the cost to you depends on many factors, including the weight of your pet, dose, and frequency of administration.  Some practices may also charge fees. The final cost to you will also depend on the cost of shipping by FedEx. The dose and frequency can be decided by a veterinarian only. In our experience, the cost to owners varies greatly depending on so many factors.

Do you know veterinarians in my area who have used PI?
Most likely, yes. We have worked with many veterinarians and have a locator of veterinarians who have experience with PI. You can find the information by clicking here.

Who distributes Polyprenyl Immunostimulant™ in the US or overseas?
Polyprenyl Immunostimulant™ is distributed by VetImmune® and by Panda Plus s.r.o. in Czechia.

How do I store Polyprenyl Immunostimulant™? 
We recommend storing Polyprenyl Immunostimulant™ refrigerated (not frozen), in the dark. 

How long is Polyprenyl Immunostimulant™ good for? 
Polyprenyl Immunostimulant™ is stable for at least 12 months after the date of manufacture. Please check the expiration date on the label.

How soon will you ship my order? 
We are doing our best to ship all orders on the day they are received. However, we have cutoff times due to local pickup schedules. We will be able to ship on the same day if we have your complete order by:
3 PM ET if you requested shipping by FedEx Ground
5 PM ET if you requested shipping by FedEx Express or FedEx International services 

We do not ship on Saturdays or Sundays or on major public holidays. All orders received after cutoff times or on days off will be processed on the next business day.

Are you shipping by UPS? DHL? USPS? 
No, we use FedEx only.

What is the cost of shipping? 
The cost of shipping depends on the service you select. FedEx allows making easy estimates using their calculator at Here’s the information you need to calculate the cost:
Weight – 1 lb for 1-2 packs of 6 vials
Packaging – FedEx Pak or FedEx Box for Express service, our own packaging for FedEx Ground. FedEx Ground shipping services are available to US customers during the warm seasons only. FedEx Ground may be available to our Canadian customers during warm seasons too.
Shipping from zip code 37830
Added: pickup, insurance for the full value, signature confirmation

Does the package need to be refrigerated? 
No. Polyprenyl Immunostimulant™ is stable at temperatures above freezing and does not need to be refrigerated during transit although we recommend storing it in the refrigerator.

It is very hot where I live. Would Polyprenyl Immunostimulant™ get spoiled if the package is left outside until I pick it up?
No. Polyprenyl Immunostimulant™ is stable at temperatures above freezing and would not spoil even at elevated temperatures during transit. However, we would not recommend leaving it outside for prolonged periods of time.

It is very cold where I live. Would Polyprenyl Immunostimulant™ get spoiled if the package is left outside until I pick it up? 
Very likely it will. Polyprenyl Immunostimulant™ is unstable at lower temperatures – it should never be frozen therefore. In some areas, we will not allow signature waivers during the cold season to ensure that the product does not get spoiled waiting outside. Freezing breaks fine micelles in the solution, and Polyprenyl Immunostimulant™ may precipitate. It will remain safe but its delivery to the organs will be affected.

May a veterinarian place an order and let the patient pay for it?
Yes. The order form provides that option. Veterinarians need to fill out the account information and order information sections and let patients complete the shipping information and payment information sections..

What type of payments do you accept?
We accept all major credit cards, Paypal, and wire transfers. Orders of $1000 or more require a Credit Card Authorization form to be submitted. Orders of $2500 or more require a wire transfer or equivalent.

Do you accept CareCredit?
No. Care Credit does not allow payments for medicines.

May I return unused Polyprenyl Immunostimulant™?
Sorry, under federal law we cannot accept returns.

Your veterinarian is the best source of information regarding the diagnosis and treatment of your cat. We will work with your veterinarian and with you to improve the health of your cat. We tried answering most commonly asked questions, but if you see that something is missing, please drop us a note at Please note: under federal law, we cannot accept returns.

See more: