Polyprenyl Immunostimulant™ safety

Polyprenyl Immunostimulant™
Safe and effective treatment

Protecting your cat: we place the safety of your cat above everything else.

Polyprenyl Immunostimulant™: a proven, exceptional safety record.

Polyprenyl Immunostimulant™ is a very safe product which has been tested and used by now in thousands of cats in 41+ countries with no reports of adverse effects. Safety studies were conducted in 390 cats located in 10 states, from single- and multiple-cat environments. The cats belonged to private owners, rescuers, breeders, or resided in sanctuaries and shelters. The cats’ ages ranged from 2 days up to 17 years, and about half of all cats were pedigreed and belonged to 7 registered breeds. Oral application of 0.5 mg/kg Polyprenyl Immunostimulant™ twice daily for 15 days was safe for cats on the study. No adverse events were reported, albeit cats may not like the taste, or the smell. How many people expect their cat to love being medicated, in overall? We know of two who craved PI which should be due to the unpredictability of cats, as we know them. No adverse events were noted in the test when five cats were given 10x of the therapeutic dose (5 mg/kg) of Polyprenyl Immunostimulant™. In multiple tests with mice, 100x therapeutic doses of Polyprenyl Immunostimulant™ have been used, and those caused no adverse effects either.

The safety of our products is our first and foremost commitment to our customers. “Safety first” for us – as with any reputable manufacturer – is the equivalent of the “first, do no harm” veterinary oath. No one should cut corners with safety, under no circumstance.

Testing Polyprenyl Immunostimulant™ for safety.

We at VetImmune® and Sass and Sass, Inc. would not consider releasing a product on the market that would not have undergone rigorous testing first. That is why our very first studies with Polyprenyl Immunostimulant™ (PPI or PI as it is known to many) were on safety. We tested its safety on cats, dogs, birds, rodents, and other animals. Why? Because both the USDA and the FDA – the two bodies that can regulate and approve, or ban, medicines for animals – have rigid requirements to safety of medicinal products and require extended tests in hundreds of animals, both in the laboratory and in owned pets so that the owners and veterinarians will note and report any problems that may occur. Because Polyprenyl Immunostimulant™ is a veterinary biologic (a product derived from living organisms and biological processes), it is regulated by the USDA.

We tested the safety of Polyprenyl Immunostimulant™ at the laboratory and saw no side effects. We then sent PPI to treat 390 cats in 10 states, across the country, from California to Michigan. The owners and veterinarians gave the cats two doses daily for 15 days. Not a single one of the 390 cats experienced an adverse health reaction to the treatment with PPI. Our safety tests met the stringent requirements of the USDA, who agreed our product is safe.

Every new serial manufactured is tested again.
Safety, with Polyprenyl Immunostimulant™ , is not an empty word.

Dr. Diane Van Horn Hendrix (University of Tennessee-Knoxville) tested clinical safety of ocular topical drops with Polyprenyl Immunostimulant. In her study, cats were applied ocular drops in each eye twice daily for 14 days. No adverse events were noted. The paper was presented at the meeting of the American College of Veterinary Ophthalmologists in 2017.

Veterinarians also study Polyprenyl Immunostimulant in other infections and other species, like dogs, ferrets, and birds. You may read about FIP research by Dr. Alfred Legendre in his papers here.

* Polyprenyl Immunostimulant™ is not or may not be available in a small number of countries due to country-specific regulations or contractual limitations.