Publications & Download
Research publications, order forms, and product brochures.
Download our documentation
From this page you can download all published research papers on the use of Polyprenyl Immunostimulant™, our order forms (US and International) as well as product information insert, brochure, and dosage card, all in one convenient location.
Research publications
Černá, P.; Ayoob, A.; Baylor, C.; Champagne, E.; Hazanow, S.; Heidel, R.E.; Wirth, K.; Legendre, A.M.; Gunn-Moore, D.A. Pathogens 2022, 11, 881. https://doi.org/10.3390/pathogens11080881 Summary/Conclusions: This study adds important data about the successful treatment of FIP with PI; it shows that PI is beneficial in the management of this disease, and reports survival analysis of these cats. The MST was 2917 days (eight years) for those cats that survived to at least 365 days. A combination of resolving anemia and normalization of A:G ratios during the PI treatment appears to be a positive prognostic indicator for survival. This study demonstrates that PI is useful in the treatment of FIP.
Addie, D.D.; Silveira, C.; Aston, C.; Brauckmann, P.; Covell-Ritchie, J.; Felstead, C.; Fosbery, M.; Gibbins, C.; Macaulay, K.; McMurrough, J.; Pattison, E.; Robertson, E. Viruses 2022, 14, 744. https://doi.org/10.3390/v14040744 Summary/Conclusions: The paper has” shown that AGP measurement will be a useful parameter to assess their efficacy”. Four cats in the recovered group and one in the remission group were treated with PI only or a combination of PI and an antiviral.
Legendre AM et al. Legendre AM, Kuritz T, Heidel RE and Baylor VM Front. Vet. Sci. 2017 4:24. doi: 10.3389/fvets.2017.00024 Summary/Conclusions: We conducted double-blinded, randomized, placebo-controlled clinical trials in experimentally infected cats to establish the efficacy of PI. Specific pathogen-free cats were administered a placebo (n = 20) or PI (n = 20) starting on the day of FHV-1 experimental challenge. Trained, masked observers applied a standardized scoring system daily in clinical examinations for 14 days after the FHV-1 challenge. The cats treated with PI had significantly lower disease severity scores over the course of the experiment compared to the cats in the placebo group (p = 0.05). The safety studies, including a field safety study involving 390 owned cats in 10 states, showed that PI was safe to use in cats as young as 8 weeks of age.
Legendre AM, Kuritz T, Galyon G, Baylor VM and Heidel RE Front. Vet. Sci. 2017 4:7. doi: 10.3389/fvets.2017.00007 Summary/Conclusions: Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria were treated with PI without intentional selection of less severe cases. The survival time from the start of PI treatment in cats diagnosed with dry FIP showed that of the 60 cats with dry FIP treated with PI, 8 survived over 200 days, and 4 of 60 survived over 300 days. The survival times were significantly longer in cats not treated with corticosteroids concurrently with PI.
Feline Health Topics: Treatment for FIP
Perkins, A. Louisiana Vet. 2017, 27 (3): 10 Summary/Conclusions: Case report: a FIP patient treated with PI and has been surviving for over 2 years at the time of the publication
Legendre AM, Bartges JW. JJFMS 2009 11, 624e626 doi:10.1016/j.jfms.2008.12.002 Summary/Conclusions: Three cats with dry form FIP were treated with Polyprenyl Immunostimulant. Two of the three cats are still on treatment and are alive and well 2 years after diagnosis. The third cat survived 14 months but was treated for only 4.5 months.
Order forms
Download this form if you are a veterinarian or a cat guardian located in the US.
Download this form if you are a veterinarian or a cat guardian located outside the US.
Documentation
Polyprenyl Immunostimulant™ package insert.
Feline Rhinotracheitis (FRV) treatment brochure.
Polyprenyl Immunostimulant™ Dosage card for Rhinotracheitis.
Cat Guardians
Order information for cat guardians
Veterinarians
Register or log in page for veterinarians
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