Polyprenyl Immunostimulant™ documentation

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Research publications, order forms, and product brochures.

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From this page you can download all published research papers on the use of Polyprenyl Immunostimulant™, our order forms (US and International) as well as product information insert, brochure, and dosage card, all in one convenient location.

Research publications

Retrospective Survival Analysis of Cats with Feline Infectious Peritonitis Treated with Polyprenyl Immunostimulant That Survived over 365 Days.

Černá, P.; Ayoob, A.; Baylor, C.; Champagne, E.; Hazanow, S.; Heidel, R.E.; Wirth, K.; Legendre, A.M.; Gunn-Moore, D.A. 
Pathogens 2022, 11, 881.
This study adds important data about the successful treatment of FIP with PI; it shows that PI is beneficial in the management of this disease, and reports survival analysis of these cats. The MST was 2917 days (eight years) for those cats that survived to at least 365 days. A combination of resolving anemia and normalization of A:G ratios during the PI treatment appears to be a positive prognostic indicator for survival. This study demonstrates that PI is useful in the treatment of FIP.

Alpha-1 Acid Glycoprotein Reduction Differentiated Recovery from Remission in a Small Cohort of Cats Treated for Feline Infectious Peritonitis

Addie, D.D.; Silveira, C.; Aston, C.; Brauckmann, P.; Covell-Ritchie, J.; Felstead, C.; Fosbery, M.; Gibbins, C.; Macaulay, K.; McMurrough, J.; Pattison, E.; Robertson, E.
Viruses 2022, 14, 744. https://doi.org/10.3390/v14040744
The paper has” shown that AGP measurement will be a useful parameter to assess their efficacy”. Four cats in the recovered group and one in the remission group were treated with PI only or a combination of PI and an antiviral.

Polyprenyl Immunostimulant in Feline Rhinotracheitis: Randomized Placebo-Controlled Experimental and Field Safety Studies

Legendre AM et al. Legendre AM, Kuritz T, Heidel RE and Baylor VM
Front. Vet. Sci. 2017 4:24.
doi: 10.3389/fvets.2017.00024
We conducted double-blinded, randomized, placebo-controlled clinical trials in experimentally infected cats to establish the efficacy of PI. Specific pathogen-free cats were administered a placebo (n = 20) or PI (n = 20) starting on the day of FHV-1 experimental challenge. Trained, masked observers applied a standardized scoring system daily in clinical examinations for 14 days after the FHV-1 challenge. The cats treated with PI had significantly lower disease severity scores over the course of the experiment compared to the cats in the placebo group (p = 0.05). The safety studies, including a field safety study involving 390 owned cats in 10 states, showed that PI was safe to use in cats as young as 8 weeks of age.

Polyprenyl Immunostimulant Treatment of Cats with Presumptive Non-Effusive Feline Infectious Peritonitis In a Field Study.

Legendre AM, Kuritz T, Galyon G, Baylor VM and Heidel RE
Front. Vet. Sci. 2017 4:7.
doi: 10.3389/fvets.2017.00007
Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria were treated with PI without intentional selection of less severe cases. The survival time from the start of PI treatment in cats diagnosed with dry FIP showed that of the 60 cats with dry FIP treated with PI, 8 survived over 200 days, and 4 of 60 survived over 300 days. The survival times were significantly longer in cats not treated with corticosteroids concurrently with PI.

Feline Health Topics: Treatment for FIP

Perkins, A.
Louisiana Vet. 2017, 27 (3): 10
Case report: a FIP patient treated with PI and has been surviving for over 2 years at the time of the publication

Effect of Polyprenyl Immunostimulant on the survival times of three cats with the dry form of feline infectious peritonitis.

Legendre AM, Bartges JW.
JJFMS 2009 11, 624e626
Three cats with dry form FIP were treated with Polyprenyl Immunostimulant. Two of the three cats are still on treatment and are alive and well 2 years after diagnosis. The third cat survived 14 months but was treated for only 4.5 months.

Order forms

US Order form

Download this form if you are a veterinarian or a cat guardian located in the US.

International Order form

Download this form if you are a veterinarian or a cat guardian located outside the US.


Package insert

Polyprenyl Immunostimulant™ package insert.

Treatment brochure

Feline Rhinotracheitis (FRV) treatment brochure.

Dosage Card

Polyprenyl Immunostimulant™ Dosage card for Rhinotracheitis.

Cat Guardians

Order information for cat guardians


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