Polyprenyl Immunostimulant™ product information


Polyprenyl Immunostimulant™ is manufactured by Sass & Sass, Inc. and is the only therapeutic approved by the USDA for the treatment of feline rhinotracheitis.

Polyprenyl Immunostimulant™ is a proven product for the treatment of Feline Rhinotracheitis, designed with cats and their guardians in mind.

What are the benefits of Polyprenyl Immunostimulant™?
Polyprenyl Immunostimulant™ is a unique veterinary treatment of feline viral rhinotracheitis (FVR, FRV, FHV-1), a common and ubiquitous upper respiratory infection (URI). Polyprenyl Immunostimulant™, also referred to as PI or PPI, was designed and developed specifically for cats.

It reduces the severity of the disease in cats by doing what antivirals cannot accomplish: Polyprenyl Immunostimulant restores the cat’s innate immunity to fight the viral infection effectively. It is a very safe, well-tolerated, easily administered small dose  oral liquid designed with cats and their guardians in mind. Because the dose needed to treat a cat is low, and the course of treatment short, this is also an affordable treatment for any cat suffering for FVR.

Polyprenyl Immunostimulant™ is formulated as a 2 mg/mL solution of phosphorylated polyprenols and is offered in 10 mL vials or packs of 6 x 10 mL vials.

How much PI do you need?

Use our calculator to find out Polyprenyl Immunostimulant™ dosage for FVR.

Why should you choose Polyprenyl Immunostimulant™?
A common option for attempting to treat Feline Viral Rhinotracheitis (FVR) is with off-label, generic human antiviral drugs that are not tailored to cats. These human drugs have known side effects on a cat’s organism; they often need to be compounded, which is costly, or come in large size pills that are definitely not cat-friendly.

Cat guardians should ask themselves this question: would you use a horse-specific medicine on yourself? If your answer is “probably not”, then why would you use a human-specific medicine on a cat when the option exists to treat the cat with feline-specific medicine? Why treat one species with medicine developed for another, completely different species?

Using human-specific medicine to treat felines is like using veterinary drugs to treat human patients: it is not recommended.
Unlike antivirals prescribed for FVR, Polyprenyl Immunostimulant™ is cat-specific.

For cat’s DVMs and VMDs, the question is similar: would MDs prescribe or even recommend a veterinary medicine to their human patients? The answer is easy: “definitely NOT,” just like dedicated veterinarians would NOT consider prescribing or use human-specific medicine for cats unless proper veterinary studies of safety and efficacy have also been conducted with that human medicine.

Human generic direct antivirals (like, for example, Famciclovir) only able to lessen the viral load during flare-ups, but they do not completely eliminate the virus. As cats and cat guardians do not read the viral titer reports, if the viral infection has destroyed the cat’s immunity, all the cat’s guardian can do is witness their cats feel equally bad regardless of the viral load.

How does Polyprenyl Immunostimulant™ work?

Polyprenyl Immunostimulant™ works by upregulating innate immunity and directing the cellular immune response. It is a very safe and effective product which has proven efficacy for the treatment of cats eight weeks of age or older against rhinotracheitis (FVR). PI also alleviates the feeling of sickness in cats by restoring the proper immune response.

If your cat (or your patient) keeps experiencing rhinotracheitis episodes, and you keep treating with antivirals, but the cat relapses time and again, it is time to address the root of the cause instead of the effect: the cat’s immune system is so compromised that it cannot mount the proper response against the virus’ attacks. Polyprenyl Immunostimulant™ treats the root of the problem, resulting in the reduction or elimination of its effects.

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